MetaCyc Pathway: superpathway of nicotine biosynthesis in Rhodosporidium toruloides IFO0880

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L-aspartate oxidase:
L-aspartate + dioxygen→2-iminosuccinate + hydrogen peroxide + H+ (EC 1.4.3.16)
No genes
Putrescine N-methyltransferase:
putrescine + S-adenosyl-L-methionine→N-methylputrescine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.53)
No genes
Quinolinate synthase:
2-iminosuccinate + glycerone phosphate→quinolinate + phosphate + 2 H2O (EC 2.5.1.72)
No genes
Diamine oxidase:
N-methylputrescine + dioxygen + H2O→N-methylaminobutanal + ammonium + hydrogen peroxide (EC 1.4.3.22)
No genes
Nicotinate-nucleotide diphosphorylase (carboxylating) (in reverse):
quinolinate + 2 H+ + 5-phospho-α-D-ribose 1-diphosphate→β-nicotinate D-ribonucleotide + CO2 + diphosphate (EC 2.4.2.19)
mRNA_1963 (10331)
N-methylaminobutanal→N-methyl-Δ1-pyrrolinium cation + H2O (spontaneous)
No genes
β-nicotinate D-ribonucleotide + H2O→nicotinate + D-ribofuranose 5-phosphate + H+ (EC 3.2.2.M4)
No genes
nicotinate + NADPH + H+→3,6-dihydronicotinate + NADP+
No genes
3,6-dihydronicotinate + 2 H+→1,2-dihydropyrimidine + CO2
No genes
1,2-dihydropyrimidine + N-methyl-Δ1-pyrrolinium cation→3,6-dihydronicotine + H+
No genes
3,6-dihydronicotine + NADP+→(S)-nicotine + NADPH + H+
No genes
(S)-nicotine + dioxygen + a reduced [NADPH-hemoprotein reductase]→(S)-nornicotine + formaldehyde + an oxidized [NADPH-hemoprotein reductase] + H2O
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information