MetaCyc Pathway: lipoate biosynthesis and incorporation IV (yeast) in Rhodosporidium toruloides IFO0880

Add experiment(s):


Lipoyl(octanoyl) transferase:
an octanoyl-[acp] + [glycine cleavage system lipoyl-carrier protein]-L-lysine→a [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + a soluble [acyl-carrier protein] + H+ (EC 2.3.1.181)
mRNA_6453 (14821)
an octanoyl-[acp] + coenzyme A→octanoyl-CoA + a soluble [acyl-carrier protein]
No genes
Lipoyl synthase:
a [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + 2 a reduced [2Fe-2S] ferredoxin + 2 S-adenosyl-L-methionine + 2 a sulfurated [sulfur carrier]→a [glycine-cleavage complex H protein] N6-[(R)-lipoyl]-L-lysine + 2 5'-deoxyadenosine + 2 L-methionine + 2 an oxidized [2Fe-2S] ferredoxin + 2 an unsulfurated [sulfur carrier] (EC 2.8.1.8)
mRNA_5728 (14096)
octanoyl-CoA + [pyruvate dehydrogenase E2 lipoyl-carrier protein]-L-lysine→a [pyruvate dehydrogenase E2 protein] N6-octanoyl-L-lysine + coenzyme A + H+
No genes
octanoyl-CoA + [2-oxoglutarate dehydrogenase E2 lipoyl-carrier protein]-L-lysine→a [2-oxoglutarate-dehydrogenase E2 protein] N6-octanoyl-L-lysine + coenzyme A + H+
No genes
Lipoyl synthase:
a [pyruvate dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 a reduced [2Fe-2S] ferredoxin + 2 S-adenosyl-L-methionine + 2 a sulfurated [sulfur carrier]→a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 5'-deoxyadenosine + 2 L-methionine + 2 an oxidized [2Fe-2S] ferredoxin + 2 an unsulfurated [sulfur carrier] (EC 2.8.1.8)
mRNA_5728 (14096)
Lipoyl synthase:
a [2-oxoglutarate-dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 a reduced [2Fe-2S] ferredoxin + 2 S-adenosyl-L-methionine + 2 a sulfurated [sulfur carrier]→a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 5'-deoxyadenosine + 2 L-methionine + 2 an oxidized [2Fe-2S] ferredoxin + 2 an unsulfurated [sulfur carrier] (EC 2.8.1.8)
mRNA_5728 (14096)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information