MetaCyc Pathway: superpathway of dTDP-glucose-derived antibiotic building blocks biosynthesis in Rhodosporidium toruloides IFO0880

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Glucose-1-phosphate thymidylyltransferase:
α-D-glucopyranose 1-phosphate + H+ + dTTP→dTDP-α-D-glucose + diphosphate
(EC 2.7.7.24)
No genes
dTDP-glucose 4,6-dehydratase:
dTDP-α-D-glucose→dTDP-4-dehydro-6-deoxy-α-D-glucopyranose + H2O
(EC 4.2.1.46)
mRNA_7050 (15418)
dTDP-4-dehydro-6-deoxy-α-D-glucopyranose→dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H+ + H2O (EC 4.2.1.159)
No genes
dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + NAD(P)H + 2 H+→dTDP-4-dehydro-2,6-dideoxy-α-D-allose + NAD(P)+
No genes
dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H+→dTDP-3,4-didehydro-2,6-dideoxy-α-D-glucose (spontaneous) (EC 4.2.1.159)
No genes
dTDP-4-dehydro-2,6-dideoxy-α-D-allose + S-adenosyl-L-methionine→dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-β-L-allose + S-adenosyl-L-homocysteine + H+
No genes
dTDP-3,4-didehydro-2,6-dideoxy-α-D-glucose + L-glutamate→dTDP-3-amino-4-dehydro-2,3,6-trideoxy-α-D-glucose + 2-oxoglutarate
No genes
dTDP-3,4-didehydro-2,6-dideoxy-α-D-glucose + NADPH + H+→dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose + NADP+ (EC 1.1.1.384)
No genes
dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→dTDP-4-dehydro-2,3,6-trideoxy-α-D-hexopyranose + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O (EC 4.2.1.164)
No genes
dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose + NADPH + H+→dTDP-α-D-olivose + NADP+
No genes
dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose→dTDP-4-dehydro-2,6-dideoxy-β-L-galactose
No genes
dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose + NADPH + H+→dTDP-α-D-oliose + NADP+
No genes
dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose + S-adenosyl-L-methionine→dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-α-D-glucose + S-adenosyl-L-homocysteine + H+
No genes
dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-β-L-allose→dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-β-L-galactose
No genes
dTDP-3-amino-4-dehydro-2,3,6-trideoxy-α-D-glucose + 2 S-adenosyl-L-methionine→dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-α-D-glucose + 2 S-adenosyl-L-homocysteine + 2 H+
No genes
dTDP-4-dehydro-2,3,6-trideoxy-α-D-hexopyranose + L-glutamate→dTDP-4-amino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranose + 2-oxoglutarate (EC 2.6.1.110)
No genes
dTDP-4-dehydro-2,6-dideoxy-β-L-galactose + NADPH + H+→dTDP-β-L-olivose + NADP+
No genes
dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-α-D-glucose + NADPH + H+→dTDP-α-D-mycarose + NADP+
No genes
dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-β-L-galactose + NADPH + H+→dTDP-β-L-mycarose + NADP+
No genes
dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-α-D-glucose→dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-β-L-glucose
No genes
dTDP-4-amino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranose + S-adenosyl-L-methionine→dTDP-N-monodesmethyl-α-D-forosamine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.324)
No genes
dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-β-L-glucose + NADPH + H+→dTDP-β-L-megosamine + NADP+
No genes
dTDP-N-monodesmethyl-α-D-forosamine + S-adenosyl-L-methionine→dTDP-α-D-forosamine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.324)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information