GTP cyclohydrolase I:
GTP + H2O→7,8-dihydroneopterin 3'-triphosphate + formate + H+ (EC 3.5.4.16) |
| mRNA_1964 (10332) |
6-pyruvoyltetrahydropterin synthase:
7,8-dihydroneopterin 3'-triphosphate→(6R)-6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate + H+ (EC 4.2.3.12) |
| No genes |
Pyrimidodiazepine synthase (in reverse):
(6R)-6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione→2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O (EC 1.5.4.1) |
| No genes |
| (6R)-6-pyruvoyl-5,6,7,8-tetrahydropterin→7,8-dihydropterin |
| No genes |
Guanine deaminase:
7,8-dihydropterin + H+ + H2O→7,8-dihydrolumazine + ammonium (EC 3.5.4.3) |
| mRNA_682 (9050) |
| mRNA_1340 (9708) |
| 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + 7,8-dihydropterin→drosopterin + H2O (spontaneous) |
| No genes |
| 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + 7,8-dihydrolumazine→aurodrosopterin + H2O (spontaneous) |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information