MetaCyc Pathway: patulin biosynthesis in Rhodosporidium toruloides IFO0880

Add experiment(s):


6-methylsalicylic acid synthase:
acetyl-CoA + 3 malonyl-CoA + NADPH + 3 H+→6-methylsalicylate + 3 CO2 + 4 coenzyme A + NADP+ + H2O (EC 2.3.1.165)
No genes
6-methylsalicylate decarboxylase:
6-methylsalicylate + H+→3-methylphenol + CO2 (EC 4.1.1.52)
No genes
3-methylphenol + dioxygen + a reduced [NADPH-hemoprotein reductase]→3-hydroxybenzyl alcohol + an oxidized [NADPH-hemoprotein reductase] + H2O
No genes
3-hydroxybenzyl alcohol + dioxygen + a reduced [NADPH-hemoprotein reductase]→gentisyl alcohol + an oxidized [NADPH-hemoprotein reductase] + H2O
No genes
gentisyl alcohol + NADP+→gentisaldehyde + NADPH + H+
No genes
gentisaldehyde + H2O→isoepoxydon
No genes
isoepoxydon + NADP+→phyllostine + NADPH + H+
No genes
phyllostine→neopatulin
No genes
neopatulin + NADPH + H+→(E)-ascladiol + NADP+
mRNA_3282 (11650)
mRNA_4507 (12875)
(E)-ascladiol + NADP+→patulin + NADPH + H+
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information