MetaCyc Pathway: superpathway of candicidin biosynthesis in Rhodosporidium toruloides IFO0880

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GDP-mannose 4,6-dehydratase:
GDP-α-D-mannose→GDP-4-dehydro-α-D-rhamnose + H2O (EC 4.2.1.47)
mRNA_2621 (10989)
mRNA_3255 (11623)
Aminodeoxychorismate synthase:
chorismate + L-glutamine→4-amino-4-deoxychorismate + L-glutamate (EC 2.6.1.85)
mRNA_5301 (13669)
acetyl-CoA + a [carboxyl-carrier protein dimer]-N6-carboxybiotinyl-L-lysine→malonyl-CoA + a [biotin carboxyl-carrier-protein dimer]-N6-biotinyl-L-lysine (EC 2.1.3.15)
No genes
Aminodeoxychorismate lyase:
4-amino-4-deoxychorismate→4-aminobenzoate + H+ + pyruvate (EC 4.1.3.38)
No genes
GDP-4-dehydro-α-D-rhamnose→GDP-3-dehydro-6-deoxy-α-D-mannose
No genes
4-aminobenzoate + ATP + coenzyme A→4-aminobenzoyl-CoA + ADP + phosphate
No genes
GDP-3-dehydro-6-deoxy-α-D-mannose + an aminated amino group donor→GDP-mycosamine + a deaminated amino group donor
No genes
4-aminobenzoyl-CoA + 15 malonyl-CoA + 4 (S)-methylmalonyl-CoA + 28 NADPH + 47 H+→candicinolide + 15 CO2 + 20 coenzyme A + 28 NADP+ + 16 H2O
No genes
candicinolide + 3 dioxygen + 5 H+ + 6 a reduced ferredoxin [iron-sulfur] cluster→18-carboxy candicinolide + 6 an oxidized ferredoxin [iron-sulfur] cluster + 4 H2O
No genes
18-carboxy candicinolide + a reduced unknown two electron carrier + dioxygen→demycosaminyl-candicidin III + an oxidized unknown electron carrier + H2O
No genes
GDP-mycosamine + demycosaminyl-candicidin III→candicidin III + GDP + H+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information