MetaCyc Pathway: viridicatumtoxin biosynthesis in Rhodosporidium toruloides IFO0880

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Dimethylallyltranstransferase:
prenyl diphosphate + 3-methylbut-3-en-1-yl diphosphate→geranyl diphosphate + diphosphate (EC 2.5.1.1)
mRNA_4576 (12944)
mRNA_8135 (16503)
malonamate + ATP + coenzyme A→malonamoyl-CoA + AMP + diphosphate
No genes
malonamoyl-CoA[cytosol] + a soluble [acyl-carrier protein][cytosol] + 8 malonyl-CoA[cytosol] + 8 H+[cytosol]→a 4-(3-acetyl-2,5,7,10-tetrahydroxy-4-oxo-3-hydroanthracen-2-yl)-3-oxobutanamyl-[acp][cytosol] + 8 CO2[cytosol] + 9 coenzyme A[cytosol] + 2 H2O[cytosol]
No genes
a 4-(3-acetyl-2,5,7,10-tetrahydroxy-4-oxo-3-hydroanthracen-2-yl)-3-oxobutanamyl-[acp][cytosol]→12a-deshydroxy-desmethylanthrotainin[cytosol] + a soluble [acyl-carrier protein][cytosol] + H+[cytosol]
No genes
12a-deshydroxy-desmethylanthrotainin + NADPH + dioxygen + H+→desmethylanthrotainin + NADP+ + H2O
No genes
desmethylanthrotainin + NADPH + dioxygen + H+→5-hydroxy-desmethylanthrotainin + NADP+ + H2O
No genes
5-hydroxy-desmethylanthrotainin + S-adenosyl-L-methionine→5-hydroxyanthrotainin + S-adenosyl-L-homocysteine + H+
No genes
5-hydroxyanthrotainin + geranyl diphosphate→previridicatumtoxin + diphosphate
No genes
previridicatumtoxin + dioxygen + a reduced [NADPH-hemoprotein reductase]→viridicatumtoxin + an oxidized [NADPH-hemoprotein reductase] + 2 H2O
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information