MetaCyc Pathway: crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered) in Rhodosporidium toruloides IFO0880

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Malate synthase:
glyoxylate + acetyl-CoA + H2O→(S)-malate + coenzyme A + H+ (EC 2.3.3.9)
mRNA_1089 (9457)
Methylmalonyl-CoA mutase:
(R)-methylmalonyl-CoA→succinyl-CoA (EC 5.4.99.2)
No genes
succinate semialdehyde + NADPH + H+→4-hydroxybutanoate + NADP+ (EC 1.1.1.co)
No genes
Acyl-CoA oxidase:
propanoyl-CoA + dioxygen→acryloyl-CoA + hydrogen peroxide (EC 1.3.3.6)
mRNA_4374 (12742)
mRNA_1332 (9700)
Methylmalonyl-CoA epimerase:
(2S)-ethylmalonyl-CoA→(2R)-ethylmalonyl-CoA (EC 5.1.99.1)
No genes
(2S)-methylsuccinyl-CoA + dioxygen→2-methylfumaryl-CoA + hydrogen peroxide (EC 1.3.3.M3)
No genes
acryloyl-CoA + CO2 + NADPH→(R)-methylmalonyl-CoA + NADP+ (EC 1.3.1.85)
No genes
4-hydroxybutanoate + ATP + coenzyme A→4-hydroxybutanoyl-CoA + ADP + phosphate (EC 6.2.1.56)
No genes
4-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.120)
No genes
succinyl-CoA + NADPH + H+→succinate semialdehyde + coenzyme A + NADP+ (EC 1.2.1.76)
No genes
CO2 + crotonyl-CoA + NADPH→(2S)-ethylmalonyl-CoA + NADP+ (EC 1.3.1.85)
No genes
(2R)-ethylmalonyl-CoA→(2S)-methylsuccinyl-CoA (EC 5.4.99.63)
No genes
2-methylfumaryl-CoA + H2O→(2R,3S)-β-methylmalyl-CoA (EC 4.2.1.148)
No genes
Malyl-CoA lyase:
(2R,3S)-β-methylmalyl-CoA→glyoxylate + propanoyl-CoA (EC 4.1.3.24)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information