MetaCyc Pathway: toxoflavin biosynthesis in Rhodosporidium toruloides IFO0880

Add experiment(s):


GTP cyclohydrolase II:
GTP + 3 H2O→2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + formate + diphosphate + 2 H+ (EC 3.5.4.25)
mRNA_4183 (12551)
mRNA_8298 (16666)
Diaminohydroxyphosphoribosylaminopyrimidine deaminase:
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H+ + H2O→5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonium (EC 3.5.4.26)
No genes
5-amino-6-(5-phosphoribosylamino)uracil reductase (in reverse):
5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH + H+→5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP+ (EC 1.1.1.193)
No genes
5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O→5-amino-6-(D-ribitylamino)uracil + phosphate (EC 3.1.3.104)
No genes
5-amino-6-(D-ribitylamino)uracil + glycine→1,6-didemethyltoxoflavin
No genes
1,6-didemethyltoxoflavin + S-adenosyl-L-methionine→reumycin + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.349)
No genes
reumycin + S-adenosyl-L-methionine→toxoflavin + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.349)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information