MetaCyc Pathway: chloramphenicol biosynthesis in Rhodosporidium toruloides IFO0880

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Aminodeoxychorismate synthase:
chorismate + L-glutamine→4-amino-4-deoxychorismate + L-glutamate (EC 2.6.1.85)
mRNA_5301 (13669)
4-amino-4-deoxychorismate→4-amino-4-deoxyprephenate (EC 5.4.99.67)
No genes
4-amino-4-deoxyprephenate + NAD+→3-(4-aminophenyl)pyruvate + CO2 + NADH + H+ (EC 1.3.1.121)
No genes
3-(4-aminophenyl)pyruvate + L-glutamate→4-amino-L-phenylalanine + 2-oxoglutarate
No genes
4-amino-L-phenylalanine + ATP + a holo-[CmlP-peptidyl-carrier protein]→4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] + AMP + diphosphate
No genes
4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] + a reduced unknown two electron carrier + dioxygen→2-(4-aminophenyl)-L-seryl-[CmlP-peptidyl-carrier-protein] + an oxidized unknown electron carrier + H2O (EC 1.14.99.65)
No genes
2-(4-aminophenyl)-L-seryl-[CmlP-peptidyl-carrier-protein] + 2 NAD(P)H + 2 H+→(1R,2R)-2-amino-1-(4-aminophenyl)propane-1,3-diol + 2 NAD(P)+ + a holo-[CmlP-peptidyl-carrier protein]
No genes
(1R,2R)-2-amino-1-(4-aminophenyl)propane-1,3-diol + dichloroacetyl-[acp]→α-N-dichloroacetyl-p-aminophenylserinol + H+ + a soluble holo-[acyl-carrier protein]
No genes
α-N-dichloroacetyl-p-aminophenylserinol + a reduced unknown two electron carrier + 2 dioxygen→chloramphenicol + an oxidized unknown electron carrier + 2 H2O (EC 1.14.99.67)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information