| 3-phospho-D-glycerate + a holo [BryA polyketide synthase] + NADPH + 2 H+→a D-lactyl-[BryA polyketide synthase] + NADP+ + phosphate + H2O |
| No genes |
[Acyl-carrier-protein] S-malonyltransferase:
malonyl-CoA + a holo [BryU acyl-carrier protein]→a malonyl-[BryU acyl-carrier protein] + coenzyme A (EC 2.3.1.39) |
| mRNA_8174 (16542) |
| mRNA_409 (8777) |
[Acyl-carrier-protein] S-malonyltransferase:
malonyl-CoA + a holo [BryP acyl-carrier protein]→a malonyl-[BryP acyl-carrier protein] + coenzyme A (EC 2.3.1.39) |
| mRNA_8174 (16542) |
| mRNA_409 (8777) |
| a D-lactyl-[BryA polyketide synthase] + 3 a malonyl-[BryP acyl-carrier protein] + 2 NADPH + 5 H+→a (5R,7R,8R)-5,7,8-trihydroxy-3-oxononanoyl-[BryA polyketide synthase] + 3 a holo [BryP acyl-carrier protein] + 3 CO2 + 2 NADP+ |
| No genes |
| a malonyl-[BryU acyl-carrier protein] + H+→an acetyl-[BryU acyl-carrier protein] + CO2 (EC 4.1.1.M15) |
| No genes |
| an acetyl-[BryU acyl-carrier protein] + a (5R,7R,8R)-5,7,8-trihydroxy-3-oxononanoyl-[BryA polyketide synthase] + H2O→a 3-acetyl-(3,5R,7R,8R)-3,5,7,8-tetrahydroxynonanoyl-[BryA polyketide synthase] + a holo [BryU acyl-carrier protein] + H+ (EC 2.3.3.M3) |
| No genes |
| a 3-acetyl-(3,5R,7R,8R)-3,5,7,8-tetrahydroxynonanoyl-[BryA polyketide synthase]→a 3-acetyl-(5R,7R,8R)-5,7,8-trihydroxynon-2-enoyl-[BryA polyketide synthase] + H2O (EC 4.2.1.M29) |
| No genes |
| a 3-acetyl-(5R,7R,8R)-5,7,8-trihydroxynon-2-enoyl-[BryA polyketide synthase] + S-adenosyl-L-methionine→a 3-methylacetyl-(5R,7R,8R)-5,7,8-trihydroxynon-2-enoyl-[BryA polyketide synthase] + S-adenosyl-L-homocysteine |
| No genes |
| a 3-methylacetyl-(5R,7R,8R)-5,7,8-trihydroxynon-2-enoyl-[BryA polyketide synthase]→a (3E,5S,7R,8R)-5,7,8-trihydroxy-3-(2-methoxy-2-oxoethylidene)nonanoyl-[BryA polyketide synthase] |
| No genes |
| a (3E,5S,7R,8R)-5,7,8-trihydroxy-3-(2-methoxy-2-oxoethylidene)nonanoyl-[BryA polyketide synthase] + 4 a malonyl-[BryP acyl-carrier protein] + a holo [BryB polyketide synthase] + 2 NADPH + 4 H+ + 2 S-adenosyl-L-methionine→a (5S,6E,11E,13S,15R,16R)-5,13,15,16-tetrahydroxy-11-(2-methoxy-2-oxoethylidene)-8,8-dimethyl-3,9-dioxoheptadec-6-enoyl-[BryB polyketide synthase] + 2 S-adenosyl-L-homocysteine + a holo [BryA polyketide synthase] + 4 a holo [BryP acyl-carrier protein] + 4 CO2 + 2 NADP+ + H2O |
| No genes |
| an acetyl-[BryU acyl-carrier protein] + a (5S,6E,11E,13S,15R,16R)-5,13,15,16-tetrahydroxy-11-(2-methoxy-2-oxoethylidene)-8,8-dimethyl-3,9-dioxoheptadec-6-enoyl-[BryB polyketide synthase] + H2O→a (6E,11E,13S,15R,16R)-3-acetyl-3,5,13,15,16-pentahydroxy-11-(2-methoxy-2-oxoethylidene)-8,8-dimethyl-9-oxoheptadec-6-enoyl-[BryB polyketide synthase] + a holo [BryU acyl-carrier protein] + H+ (EC 2.3.3.M3) |
| No genes |
| a (6E,11E,13S,15R,16R)-3-acetyl-3,5,13,15,16-pentahydroxy-11-(2-methoxy-2-oxoethylidene)-8,8-dimethyl-9-oxoheptadec-6-enoyl-[BryB polyketide synthase]→a (6E,11E,13S,15R,16R)-3-acetyl-5,13,15,16-tetrahydroxy-11-(2-methoxy-2-oxoethylidene)-8,8-dimethyl-9-oxoheptadec-2,6-dienoyl-[BryB polyketide synthase] + H2O (EC 4.2.1.M29) |
| No genes |
| a (6E,11E,13S,15R,16R)-3-acetyl-5,13,15,16-tetrahydroxy-11-(2-methoxy-2-oxoethylidene)-8,8-dimethyl-9-oxoheptadec-2,6-dienoyl-[BryB polyketide synthase] + S-adenosyl-L-methionine→a (6E,11E,13S,15R,16R)-3-methylacetyl-5,13,15,16-tetrahydroxy-11-(2-methoxy-2-oxoethylidene)-8,8-dimethyl-9-oxoheptadec-2,6-dienoyl-[BryB polyketide synthase] + S-adenosyl-L-homocysteine |
| No genes |
| a (6E,11E,13S,15R,16R)-3-methylacetyl-5,13,15,16-tetrahydroxy-11-(2-methoxy-2-oxoethylidene)-8,8-dimethyl-9-oxoheptadec-2,6-dienoyl-[BryB polyketide synthase]→a (3E,6E,11E,13S,15R,16R)-5,13,15,16-tetrahydroxy-3,11-di(2-methoxy-2-oxoethylidene)-8,8-dimethyl-9-oxoheptadec-2,6-dienoyl-[BryB polyketide synthase] |
| No genes |
| a (3E,6E,11E,13S,15R,16R)-5,13,15,16-tetrahydroxy-3,11-di(2-methoxy-2-oxoethylidene)-8,8-dimethyl-9-oxoheptadec-2,6-dienoyl-[BryB polyketide synthase] + a malonyl-[BryP acyl-carrier protein] + a holo [BryC polyketide synthase] + NADPH + 2 H+→a (2E,5Z,7S,8E,13E,15S,17R,18R)-7,15,17,18-tetrahydroxy-5,13-bis(2-methoxy-2-oxoethylidene)-10,10-dimethyl-11-oxononadeca-2,8-dienoyl-[BryC PKS] + a holo [BryB polyketide synthase] + a holo [BryP acyl-carrier protein] + CO2 + NADP+ + H2O |
| No genes |
| a malonyl-[BryP acyl-carrier protein] + a (2E,5Z,7S,8E,13E,15S,17R,18R)-7,15,17,18-tetrahydroxy-5,13-bis(2-methoxy-2-oxoethylidene)-10,10-dimethyl-11-oxononadeca-2,8-dienoyl-[BryC PKS] + 2 S-adenosyl-L-methionine→a 4-[(4Z)-4-(2-methoxy-2-oxoethylidene)-6-[(1E,6E)-8-methoxy-3,3-dimethyl-4,8-dioxo-6-[(2S,4R,5R)-2,4,5-trihydroxyhexyl]octa-1,6-dien-1-yl]oxan-2-yl]-2,2-dimethyl-3-oxobutanoyl-[BryC PKS] + 2 S-adenosyl-L-homocysteine + a holo [BryP acyl-carrier protein] + CO2 + H+ |
| No genes |
| 2 a malonyl-[BryP acyl-carrier protein] + a 4-[(4Z)-4-(2-methoxy-2-oxoethylidene)-6-[(1E,6E)-8-methoxy-3,3-dimethyl-4,8-dioxo-6-[(2S,4R,5R)-2,4,5-trihydroxyhexyl]octa-1,6-dien-1-yl]oxan-2-yl]-2,2-dimethyl-3-oxobutanoyl-[BryC PKS] + NADPH + 3 H+→a 5-hydroxy-8-[(4Z)-4-(2-methoxy-2-oxoethylidene)-6-[(1E,6E)-8-methoxy-3,3-dimethyl-4,8-dioxo-6-[(2S,4R,5R)-2,4,5-trihydroxyhexyl]octa-1,6-dien-1-yl]oxan-2-yl]-6,6-dimethyl-3,7-dioxooctanoyl-[BryC PKS] + 2 a holo [BryP acyl-carrier protein] + 2 CO2 + NADP+ |
| No genes |
| a malonyl-[BryP acyl-carrier protein] + a 5-hydroxy-8-[(4Z)-4-(2-methoxy-2-oxoethylidene)-6-[(1E,6E)-8-methoxy-3,3-dimethyl-4,8-dioxo-6-[(2S,4R,5R)-2,4,5-trihydroxyhexyl]octa-1,6-dien-1-yl]oxan-2-yl]-6,6-dimethyl-3,7-dioxooctanoyl-[BryC PKS] + a holo [BryD polyketide synthase] + 2 NADPH + 3 H+→a 3,5,7-trihydroxy-10-[(4Z)-4-(2-methoxy-2-oxoethylidene)-6-[(1E,6E)-8-methoxy-3,3-dimethyl-4,8-dioxo-6-[(2S,4R,5R)-2,4,5-trihydroxyhexyl]octa-1,6-dien-1-yl]oxan-2-yl]-8,8-dimethyl-9-oxodecanoyl-[BryD PKS] + a holo [BryC polyketide synthase] + a holo [BryP acyl-carrier protein] + CO2 + 2 NADP+ |
| No genes |
| a 3,5,7-trihydroxy-10-[(4Z)-4-(2-methoxy-2-oxoethylidene)-6-[(1E,6E)-8-methoxy-3,3-dimethyl-4,8-dioxo-6-[(2S,4R,5R)-2,4,5-trihydroxyhexyl]octa-1,6-dien-1-yl]oxan-2-yl]-8,8-dimethyl-9-oxodecanoyl-[BryD PKS]→bryostatin 0 + a holo [BryD polyketide synthase] |
| No genes |