[Acyl-carrier-protein] S-malonyltransferase:
malonyl-CoA + a holo [PedD acyl-carrier protein]→a malonyl-[PedD acyl-carrier protein] + coenzyme A (EC 2.3.1.39) |
| mRNA_8174 (16542) |
| mRNA_409 (8777) |
[Acyl-carrier-protein] S-malonyltransferase:
malonyl-CoA + a holo [PedN acyl-carrier protein]→a malonyl[PedN acyl-carrier protein] + coenzyme A (EC 2.3.1.39) |
| mRNA_8174 (16542) |
| mRNA_409 (8777) |
| 2 a malonyl-[PedD acyl-carrier protein] + acetyl-CoA + NADPH + 2 H+ + a holo [PedI polyketide synthase] + S-adenosyl-L-methionine→(4S,5R)-5-hydroxy-4-methyl-3-oxohexanoyl-[PedI polyketide synthase] + S-adenosyl-L-homocysteine + 2 CO2 + coenzyme A + NADP+ + 2 a holo [PedD acyl-carrier protein] |
| No genes |
| a malonyl[PedN acyl-carrier protein] + H+→an acetyl-[PedN acyl-carrier protein] + CO2 (EC 4.1.1.M15) |
| No genes |
| an acetyl-[PedN acyl-carrier protein] + (4S,5R)-5-hydroxy-4-methyl-3-oxohexanoyl-[PedI polyketide synthase] + H2O→3-hydroxy-3-[(2S,3R)-3-hydroxybutan-2-yl]pentanedioyl-[PedI polyketide synthase] + H+ + a holo [PedD acyl-carrier protein] |
| No genes |
| 3-hydroxy-3-[(2S,3R)-3-hydroxybutan-2-yl]pentanedioyl-[PedI polyketide synthase]→(2E)-3-[(2R,3R)-3-hydroxybutan-2-yl]pent-2-enedioyl-[PedI polyketide synthase] + H2O (EC 4.2.1.M29) |
| No genes |
| (2E)-3-[(2R,3R)-3-hydroxybutan-2-yl]pent-2-enedioyl-[PedI polyketide synthase] + H+→(4R,5R)-5-hydroxy-4-methyl-3-methylidenehexanoyl-[PedI polyketide synthase] + CO2 |
| No genes |
| a malonyl-[PedD acyl-carrier protein] + (4R,5R)-5-hydroxy-4-methyl-3-methylidenehexanoyl-[PedI polyketide synthase] + H+→a 2-[(2R,5R,6R)-2-hydroxy-5,6-dimethyl-4-methylideneoxan-2-yl]acetyl-[PedI polyketide synthase] + CO2 + a holo [PedD acyl-carrier protein] |
| No genes |
| a 2-[(2R,5R,6R)-2-hydroxy-5,6-dimethyl-4-methylideneoxan-2-yl]acetyl-[PedI polyketide synthase] + ATP + glycine + a holo [PedF polyketide synthase]→a 2-{2-[(2R,5R,6R)-2-hydroxy-5,6-dimethyl-4-methylideneoxan-2-yl]acetamido}acetyl-[PedF polyketide synthase] + AMP + diphosphate + H+ + a holo [PedI polyketide synthase] (EC 2.3.1.M81) |
| No genes |
| 3 a malonyl-[PedD acyl-carrier protein] + a 2-{2-[(2R,5R,6R)-2-hydroxy-5,6-dimethyl-4-methylideneoxan-2-yl]acetamido}acetyl-[PedF polyketide synthase] + 3 NADPH + 4 H+ + 2 S-adenosyl-L-methionine→a (2E,5R,7S)-5,7-dihydroxy-8-{2-[(2R,5R,6R)-2-hydroxy-5,6-dimethyl-4-methylideneoxan-2-yl]acetamido}-4,4-dimethyloct-2-enoyl-[PedF polyketide synthase] + 2 S-adenosyl-L-homocysteine + 3 CO2 + 3 NADP+ + 3 a holo [PedD acyl-carrier protein] + H2O (EC 2.3.1.M81) |
| No genes |
| a malonyl-[PedD acyl-carrier protein] + a (2E,5R,7S)-5,7-dihydroxy-8-{2-[(2R,5R,6R)-2-hydroxy-5,6-dimethyl-4-methylideneoxan-2-yl]acetamido}-4,4-dimethyloct-2-enoyl-[PedF polyketide synthase] + NADPH + 2 H+→a (3S)-3-hydroxy-4-[(4R,6S)-4-hydroxy-6-({2-[(2R,5R,6R)-2-hydroxy-5,6-dimethyl-4-methylideneoxan-2-yl]acetamido}methyl)-3,3-dimethyloxan-2-yl]butanoyl-[PedF polyketide synthase] + CO2 + NADP+ + a holo [PedD acyl-carrier protein] (EC 2.3.1.M81) |
| No genes |
| a (3S)-3-hydroxy-4-[(4R,6S)-4-hydroxy-6-({2-[(2R,5R,6R)-2-hydroxy-5,6-dimethyl-4-methylideneoxan-2-yl]acetamido}methyl)-3,3-dimethyloxan-2-yl]butanoyl-[PedF polyketide synthase] + NADPH + dioxygen + H+→pederin precursor + CO2 + NADP+ + a holo [PedF polyketide synthase] |
| No genes |
| pederin precursor→pseudopederin |
| No genes |
| pseudopederin + S-adenosyl-L-methionine→pederin + S-adenosyl-L-homocysteine + H+ |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information