MetaCyc Pathway: biotin biosynthesis from 8-amino-7-oxononanoate III in Rhodosporidium toruloides IFO0880

Add experiment(s):


(8S)-8-amino-7-oxononanoate + NAD(P)H + a [protein]-L-lysine→a [protein]-N6-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysine + NAD(P)+ + H2O (EC 2.6.1.al)
No genes
a [protein]-N6-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysine + CO2 + NAD(P)+ + H2O→(7R,8S)-8-amino-7-(carboxyamino)nonanoate + a [protein]-(S)-2-amino-6-oxohexanoate + NAD(P)H + 2 H+ (EC 2.6.1.al)
No genes
Dethiobiotin synthase:
(7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP→dethiobiotin + ADP + H+ + phosphate (EC 6.3.3.3)
mRNA_4363 (12731)
Biotin synthase:
dethiobiotin + H+ + 2 a reduced [2Fe-2S] ferredoxin + S-adenosyl-L-methionine + a sulfurated [sulfur carrier]→4,5-secobiotin + 5'-deoxyadenosine + L-methionine + 2 an oxidized [2Fe-2S] ferredoxin + an unsulfurated [sulfur carrier] (EC 2.8.1.6)
mRNA_7540 (15908)
Biotin synthase:
4,5-secobiotin + S-adenosyl-L-methionine→biotin + 5'-deoxyadenosine + L-methionine + H+ (EC 2.8.1.6)
mRNA_7540 (15908)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information