MetaCyc Pathway: androstenedione degradation II (anaerobic) in Rhodosporidium toruloides IFO0880

Add experiment(s):


3-oxosteroid 1-dehydrogenase:
androstenedione + an oxidized unknown electron carrier→androsta-1,4-diene-3,17-dione + a reduced unknown two electron carrier
(EC 1.3.99.4)
No genes
3-oxo-5-alpha-steroid 4-dehydrogenase (in reverse):
androsta-1,4-diene-3,17-dione + a reduced unknown two electron carrier→androsta-1-ene-3,17-dione + an oxidized unknown electron carrier
(EC 1.3.99.5)
No genes
androsta-1-ene-3,17-dione + H2O→1-hydroxyandrostan-3,17-dione (EC 1.17.99.11)
No genes
1-hydroxyandrostan-3,17-dione + an oxidized unknown electron carrier→androstan-1,3,17-trione + a reduced unknown two electron carrier (EC 1.17.99.11)
No genes
androstan-1,3,17-trione + H2O→1,17-dioxo-2,3-seco-androstan-3-oate + H+
No genes
1,17-dioxo-2,3-seco-androstan-3-oate + ATP + coenzyme A→1,17-dioxo-2,3-seco-androstan-3-oyl-CoA + AMP + diphosphate
No genes
1,17-dioxo-2,3-seco-androstan-3-oyl-CoA + an oxidized unknown electron carrier→1,17-dioxo-2,3-seco-androsta-4-en-3-oyl-CoA + a reduced unknown two electron carrier
No genes
1,17-dioxo-2,3-seco-androsta-4-en-3-oyl-CoA + H2O→4-hydroxy-1,17-dioxo-2,3-seco-androstan-3-oyl-CoA
No genes
4-hydroxy-1,17-dioxo-2,3-seco-androstan-3-oyl-CoA→2,5-seco-3,4-dinorandrost-1,5,17-trione + acetyl-CoA
No genes
2,5-seco-3,4-dinorandrost-1,5,17-trione→3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate
No genes
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + coenzyme A→3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate (EC 6.2.1.41)
No genes
3-beta-hydroxy-Delta(5)-steroid dehydrogenase (in reverse):
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + NADPH + H+→3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + NADP+
(EC 1.1.1.145)
No genes
3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + an oxidized unknown electron carrier→(2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + a reduced unknown two electron carrier
No genes
(2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + H2O→3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-hydroxypropanoyl-CoA
No genes
3-hydroxyacyl-CoA dehydrogenase:
3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-hydroxypropanoyl-CoA + NAD+→3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-oxopropanoyl-CoA + NADH + H+
(EC 1.1.1.35)
mRNA_2835 (11203)
3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-oxopropanoyl-CoA + H2O→3aα-H-4α-carboxy-5-hydroxy-7aβ-methylhexahydro-1-indanone + acetyl-CoA + H+
No genes
3aα-H-4α-carboxy-5-hydroxy-7aβ-methylhexahydro-1-indanone + ATP + coenzyme A→(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + AMP + diphosphate
No genes
(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD+→(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA + NADH + H+
No genes
(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA + NAD+→(5R,7aS)-7a-methyl-1,5-dioxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA + NADH + H+
No genes
(5R,7aS)-7a-methyl-1,5-dioxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA + H2O→(3R)-2-(2-carboxyethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H+
No genes
(3R)-2-(2-carboxyethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O→9-carboxy-6-methyl-3,7-dioxononanoyl-CoA
No genes
Acetyl-CoA C-acyltransferase (in reverse):
9-carboxy-6-methyl-3,7-dioxononanoyl-CoA + coenzyme A→7-carboxy-4-methyl-5-oxoheptanoyl-CoA + acetyl-CoA
(EC 2.3.1.16)
mRNA_5445 (13813)
mRNA_5687 (14055)
mRNA_6860 (15228)
mRNA_310 (8678)
mRNA_517 (8885)
mRNA_697 (9065)
7-carboxy-4-methyl-5-oxoheptanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-7-carboxy-4-methyl-5-oxohept-2-enoyl-CoA + a reduced electron-transfer flavoprotein
No genes
(2E)-7-carboxy-4-methyl-5-oxohept-2-enoyl-CoA + H2O→(3R)-7-carboxy-3-hydroxy-4-methyl-5-oxoheptanoyl-CoA (EC 4.2.1.119)
No genes
3-hydroxyacyl-CoA dehydrogenase:
(3R)-7-carboxy-3-hydroxy-4-methyl-5-oxoheptanoyl-CoA + NAD+→7-carboxy-4-methyl-3,5-dioxoheptanoyl-CoA + NADH + H+
(EC 1.1.1.35)
mRNA_2835 (11203)
Acetyl-CoA C-acyltransferase (in reverse):
7-carboxy-4-methyl-3,5-dioxoheptanoyl-CoA + coenzyme A→5-carboxy-2-methyl-3-oxopentanoyl-CoA + acetyl-CoA
(EC 2.3.1.16)
mRNA_5445 (13813)
mRNA_5687 (14055)
mRNA_6860 (15228)
mRNA_310 (8678)
mRNA_517 (8885)
mRNA_697 (9065)
5-carboxy-2-methyl-3-oxopentanoyl-CoA + coenzyme A→succinyl-CoA + propanoyl-CoA
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information