MetaCyc Pathway: avenanthramide biosynthesis in Rhodosporidium toruloides IFO0880

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Phenylalanine ammonia-lyase:
L-phenylalanine→cinnamate + ammonium (EC 4.3.1.24; 4.3.1.25; 5.4.3.10)
mRNA_8094 (16462)
cinnamate + dioxygen + a reduced [NADPH-hemoprotein reductase]→4-coumarate + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.91)
No genes
4-coumarate--CoA ligase:
4-coumarate + ATP + coenzyme A→(E)-4-coumaroyl-CoA + AMP + diphosphate (EC 6.2.1.12)
No genes
Shikimate O-hydroxycinnamoyltransferase:
(E)-4-coumaroyl-CoA + shikimate→trans-5-O-(4-coumaroyl)shikimate + coenzyme A (EC 2.3.1.133)
No genes
(E)-4-coumaroyl-CoA + 5-hydroxyanthranilate→avenanthramide A + coenzyme A (EC 2.3.1.302)
No genes
trans-5-O-(4-coumaroyl)shikimate + dioxygen + a reduced [NADPH-hemoprotein reductase]→5-O-caffeoylshikimate + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.96)
No genes
5-O-caffeoylshikimate + coenzyme A→(E)-caffeoyl-CoA + shikimate
No genes
(E)-caffeoyl-CoA + 5-hydroxyanthranilate→avenanthramide C + coenzyme A (EC 2.3.1.302)
No genes
Caffeoyl-CoA O-methyltransferase:
avenanthramide C + S-adenosyl-L-methionine→avenanthramide B + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.104)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information