MetaCyc Pathway: reductive glycine pathway in Rhodosporidium toruloides IFO0880

Add experiment(s):


CO2 + H+ + 2 a reduced cytochrome c-553→formate + 2 an oxidized cytochrome c-553 (EC 1.17.2.3)
No genes
Formate--tetrahydrofolate ligase:
formate + ATP + a tetrahydrofolate→an N10-formyltetrahydrofolate + ADP + phosphate (EC 6.3.4.3)
mRNA_6998 (15366)
Methenyltetrahydrofolate cyclohydrolase (in reverse):
an N10-formyltetrahydrofolate + H+→a 5,10-methenyltetrahydrofolate + H2O (EC 3.5.4.9)
mRNA_4257 (12625)
mRNA_6998 (15366)
Methylenetetrahydrofolate dehydrogenase (NADP(+)) (in reverse):
a 5,10-methenyltetrahydrofolate + NADPH→a 5,10-methylenetetrahydrofolate + NADP+ (EC 1.5.1.5)
mRNA_4257 (12625)
mRNA_6998 (15366)
CO2 + a 5,10-methylenetetrahydrofolate + ammonium + NADH→glycine + NAD+ + a tetrahydrofolate (EC 1.4.1.27)
mRNA_1672 (10040)
Glycine reductase (in reverse):
glycine + H+ + phosphate + a reduced thioredoxin→acetyl phosphate + ammonium + an oxidized thioredoxin + H2O (EC 1.21.4.2)
No genes
Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)
mRNA_5015 (13383)
Acetate--CoA ligase:
acetate + ATP + coenzyme A→acetyl-CoA + AMP + diphosphate (EC 6.2.1.1)
mRNA_6223 (14591)
mRNA_6229 (14597)
mRNA_7532 (15900)
Pyruvate synthase (in reverse):
acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information