MetaCyc Pathway: superpathway of purine nucleotides de novo biosynthesis I in Rhodosporidium toruloides IFO0880

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Amidophosphoribosyltransferase (in reverse):
5-phospho-α-D-ribose 1-diphosphate + L-glutamine + H2O→5-phospho-β-D-ribosylamine + L-glutamate + diphosphate (EC 2.4.2.14)
mRNA_6932 (15300)
Phosphoribosylamine--glycine ligase:
5-phospho-β-D-ribosylamine + glycine + ATP→N1-(5-phospho-β-D-ribosyl)glycinamide + ADP + H+ + phosphate (EC 6.3.4.13)
mRNA_5891 (14259)
Phosphoribosylglycinamide formyltransferase:
N1-(5-phospho-β-D-ribosyl)glycinamide + an N10-formyltetrahydrofolate→N2-formyl-N1-(5-phospho-β-D-ribosyl)glycinamide + H+ + a tetrahydrofolate (EC 2.1.2.2)
mRNA_5227 (13595)
Phosphoribosylformylglycinamidine synthase:
N2-formyl-N1-(5-phospho-β-D-ribosyl)glycinamide + ATP + L-glutamine + H2O→2-(formamido)-N1-(5-phospho-β-D-ribosyl)acetamidine + ADP + L-glutamate + H+ + phosphate (EC 6.3.5.3)
mRNA_6665 (15033)
Phosphoribosylformylglycinamidine cyclo-ligase:
2-(formamido)-N1-(5-phospho-β-D-ribosyl)acetamidine + ATP→5-amino-1-(5-phospho-β-D-ribosyl)imidazole + ADP + H+ + phosphate (EC 6.3.3.1)
mRNA_5891 (14259)
Phosphoribosylaminoimidazole carboxylase (in reverse):
5-amino-1-(5-phospho-β-D-ribosyl)imidazole + CO2→5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H+ (EC 4.1.1.21)
mRNA_3764 (12132)
Phosphoribosylaminoimidazolesuccinocarboxamide synthase:
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate→5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole + ADP + H+ + phosphate (EC 6.3.2.6)
mRNA_852 (9220)
Adenylosuccinate lyase:
5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole→5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + fumarate (EC 4.3.2.2)
mRNA_7437 (15805)
Phosphoribosylaminoimidazolecarboxamide formyltransferase:
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + an N10-formyltetrahydrofolate→5-formamido-1-(5-phospho-D-ribosyl)-imidazole-4-carboxamide + a tetrahydrofolate (EC 2.1.2.3)
mRNA_4053 (12421)
IMP cyclohydrolase (in reverse):
5-formamido-1-(5-phospho-D-ribosyl)-imidazole-4-carboxamide→IMP + H2O (EC 3.5.4.10)
mRNA_4053 (12421)
Adenylosuccinate synthase:
IMP + L-aspartate + GTP→adenylo-succinate + GDP + 2 H+ + phosphate (EC 6.3.4.4)
mRNA_3802 (12170)
IMP dehydrogenase:
IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205)
mRNA_27 (8395)
Adenylosuccinate lyase:
adenylo-succinate→AMP + fumarate (EC 4.3.2.2)
mRNA_7437 (15805)
GMP synthase (glutamine-hydrolyzing):
XMP + ATP + L-glutamine + H2O→GMP + AMP + L-glutamate + diphosphate + 2 H+ (EC 6.3.5.2)
mRNA_7388 (15756)
Adenylate kinase:
AMP + ATP→2 ADP (EC 2.7.4.3)
mRNA_3932 (12300)
mRNA_4072 (12440)
mRNA_4822 (13190)
mRNA_5739 (14107)
mRNA_6761 (15129)
mRNA_7128 (15496)
mRNA_7396 (15764)
mRNA_1365 (9733)
Guanylate kinase:
GMP + ATP→GDP + ADP (EC 2.7.4.8)
mRNA_3157 (11525)
Ribonucleoside-diphosphate reductase (in reverse):
ADP + a reduced thioredoxin→dADP + an oxidized thioredoxin + H2O (EC 1.17.4.1)
mRNA_2804 (11172)
mRNA_2922 (11290)
mRNA_5869 (14237)
Nucleoside-diphosphate kinase:
GDP + ATP→GTP + ADP (EC 2.7.4.6)
mRNA_7311 (15679)
mRNA_575 (8943)
Ribonucleoside-diphosphate reductase (in reverse):
GDP + a reduced thioredoxin→dGDP + an oxidized thioredoxin + H2O (EC 1.17.4.1)
mRNA_2804 (11172)
mRNA_2922 (11290)
mRNA_5869 (14237)
Nucleoside-diphosphate kinase:
dADP + ATP→ADP + dATP (EC 2.7.4.6)
mRNA_7311 (15679)
mRNA_575 (8943)
Nucleoside-diphosphate kinase:
dGDP + ATP→dGTP + ADP (EC 2.7.4.6)
mRNA_7311 (15679)
mRNA_575 (8943)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information