MetaCyc Pathway: mevalonate pathway I (eukaryotes and bacteria) in Rhodosporidium toruloides IFO0880

Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)

Hydroxymethylglutaryl-CoA synthase:
acetoacetyl-CoA + acetyl-CoA + H₂O→(S)-3-hydroxy-3-methylglutaryl-CoA + coenzyme A + H⁺ (EC 2.3.3.10)

mRNA_3754 (12122)

Hydroxymethylglutaryl-CoA reductase (NADPH) (in reverse):
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H⁺→(R)-mevalonate + coenzyme A + 2 NADP⁺ (EC 1.1.1.34)

mRNA_1206 (9574)

Mevalonate kinase:
(R)-mevalonate + ATP→(R)-5-phosphomevalonate + ADP + H⁺ (EC 2.7.1.36)

mRNA_390 (8758)

Phosphomevalonate kinase:
(R)-5-phosphomevalonate + ATP→(R)-mevalonate diphosphate + ADP (EC 2.7.4.2)

mRNA_334 (8702)

Diphosphomevalonate decarboxylase:
(R)-mevalonate diphosphate + ATP→3-methylbut-3-en-1-yl diphosphate + ADP + CO₂ + phosphate (EC 4.1.1.33)

mRNA_3542 (11910)

Isopentenyl-diphosphate Delta-isomerase:
3-methylbut-3-en-1-yl diphosphate→prenyl diphosphate (EC 5.3.3.2)

mRNA_7835 (16203)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information