MetaCyc Pathway: aliphatic glucosinolate biosynthesis, side chain elongation cycle in Rhodosporidium toruloides IFO0880

Add experiment(s):


5-(methylsulfanyl)-2-oxopentanoate + acetyl-CoA + H2O→2-[(3'-methylsulfanyl)propyl]malate + coenzyme A + H+ (EC 2.3.3.17)
No genes
2-[(3'-methylsulfanyl)propyl]malate→2-[(2'-methylsulfanyl)propyl]maleate + H2O (EC 4.2.1.170)
No genes
2-[(2'-methylsulfanyl)propyl]maleate + H2O→3-[(3'-methylsulfanyl)propyl]malate (EC 4.2.1.170)
No genes
3-isopropylmalate dehydrogenase:
3-[(3'-methylsulfanyl)propyl]malate + NAD+→3-carboxy-6-(methylsulfanyl)-2-oxohexanoate + NADH + H+ (EC 1.1.1.85)
mRNA_2060 (10428)
mRNA_5526 (13894)
3-isopropylmalate dehydrogenase:
3-carboxy-6-(methylsulfanyl)-2-oxohexanoate + H+→6-(methylsulfanyl)-2-oxohexanoate + CO2 (spontaneous) (EC 1.1.1.85)
mRNA_2060 (10428)
mRNA_5526 (13894)
6-(methylsulfanyl)-2-oxohexanoate + acetyl-CoA + H2O→2-[(4'-methylsulfanyl)butyl]malate + coenzyme A + H+ (EC 2.3.3.17)
No genes
6-(methylsulfanyl)-2-oxohexanoate + a proteinogenic amino acid→L-dihomomethionine + a 2-oxo carboxylate
No genes
2-[(4'-methylsulfanyl)butyl]malate→2-[(2'-methylsulfanyl)butyl]maleate + H2O (EC 4.2.1.170)
No genes
2-[(2'-methylsulfanyl)butyl]maleate + H2O→3-[(4'-methylsulfanyl)butyl]malate (EC 4.2.1.170)
No genes
3-isopropylmalate dehydrogenase:
3-[(4'-methylsulfanyl)butyl]malate + NAD+→3-carboxy-7-(methylsulfanyl)-2-oxoheptanoate + NADH + H+ (EC 1.1.1.85)
mRNA_2060 (10428)
mRNA_5526 (13894)
3-isopropylmalate dehydrogenase:
3-carboxy-7-(methylsulfanyl)-2-oxoheptanoate + H+→7-(methylsulfanyl)-2-oxoheptanoate + CO2 (spontaneous) (EC 1.1.1.85)
mRNA_2060 (10428)
mRNA_5526 (13894)
7-(methylsulfanyl)-2-oxoheptanoate + acetyl-CoA + H2O→2-[(5'-methylsulfanyl)pentyl]malate + coenzyme A + H+ (EC 2.3.3.17)
No genes
7-(methylsulfanyl)-2-oxoheptanoate + a proteinogenic amino acid→L-trihomomethionine + a 2-oxo carboxylate
No genes
2-[(5'-methylsulfanyl)pentyl]malate→2-[(2'-methylsulfanyl)pentyl]maleate + H2O (EC 4.2.1.170)
No genes
2-[(2'-methylsulfanyl)pentyl]maleate + H2O→3-[(5'-methylsulfanyl)pentyl]malate (EC 4.2.1.170)
No genes
3-isopropylmalate dehydrogenase:
3-[(5'-methylsulfanyl)pentyl]malate + NAD+→3-carboxy-8-(methylsulfanyl)-2-oxooctanoate + NADH + H+ (EC 1.1.1.85)
mRNA_2060 (10428)
mRNA_5526 (13894)
3-isopropylmalate dehydrogenase:
3-carboxy-8-(methylsulfanyl)-2-oxooctanoate + H+→8-(methylsulfanyl)-2-oxooctanoate + CO2 (spontaneous) (EC 1.1.1.85)
mRNA_2060 (10428)
mRNA_5526 (13894)
8-(methylsulfanyl)-2-oxooctanoate + acetyl-CoA + H2O→2-[(6'-methylsulfanyl)hexyl]malate + coenzyme A + H+ (EC 2.3.3.17)
No genes
8-(methylsulfanyl)-2-oxooctanoate + a proteinogenic amino acid→L-tetrahomomethionine + a 2-oxo carboxylate
No genes
2-[(6'-methylsulfanyl)hexyl]malate→2-[(2'-methylsulfanyl)hexyl]maleate + H2O (EC 4.2.1.170)
No genes
2-[(2'-methylsulfanyl)hexyl]maleate + H2O→3-[(6'-methylsulfanyl)hexyl]malate (EC 4.2.1.170)
No genes
3-isopropylmalate dehydrogenase:
3-[(6'-methylsulfanyl)hexyl]malate + NAD+→3-carboxy-9-(methylsulfanyl)-2-oxononanoate + NADH + H+ (EC 1.1.1.85)
mRNA_2060 (10428)
mRNA_5526 (13894)
3-isopropylmalate dehydrogenase:
3-carboxy-9-(methylsulfanyl)-2-oxononanoate + H+→9-(methylsulfanyl)-2-oxononanoate + CO2 (spontaneous) (EC 1.1.1.85)
mRNA_2060 (10428)
mRNA_5526 (13894)
9-(methylsulfanyl)-2-oxononanoate + acetyl-CoA + H2O→2-[(7'-methylsulfanyl)heptyl]malate + coenzyme A + H+ (EC 2.3.3.17)
No genes
9-(methylsulfanyl)-2-oxononanoate + a proteinogenic amino acid→L-pentahomomethionine + a 2-oxo carboxylate
No genes
2-[(7'-methylsulfanyl)heptyl]malate→2-[(2'-methylsulfanyl)heptyl]maleate + H2O (EC 4.2.1.170)
No genes
2-[(2'-methylsulfanyl)heptyl]maleate + H2O→3-[(7'-methylsulfanyl)heptyl]malate (EC 4.2.1.170)
No genes
3-isopropylmalate dehydrogenase:
3-[(7'-methylsulfanyl)heptyl]malate + NAD+→3-carboxy-10-(methylsulfanyl)-2-oxodecanoate + NADH + H+ (EC 1.1.1.85)
mRNA_2060 (10428)
mRNA_5526 (13894)
3-isopropylmalate dehydrogenase:
3-carboxy-10-(methylsulfanyl)-2-oxodecanoate + H+→10-(methylsulfanyl)-2-oxodecanoate + CO2 (spontaneous) (EC 1.1.1.85)
mRNA_2060 (10428)
mRNA_5526 (13894)
10-(methylsulfanyl)-2-oxodecanoate + a proteinogenic amino acid→L-hexahomomethionine + a 2-oxo carboxylate
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information