MetaCyc Pathway: superpathway of L-threonine metabolism in Rhodosporidium toruloides IFO0880

Add experiment(s):


Threonine ammonia-lyase:
L-threonine→(2Z)-2-aminobut-2-enoate + H+ + H2O (EC 4.3.1.19)
mRNA_3541 (11909)
mRNA_4566 (12934)
L-threonine + ATP→L-threonine 3-O-phosphate + ADP + H+ (EC 2.7.1.177)
No genes
L-threonine 3-dehydrogenase:
L-threonine + NAD+→L-2-amino-3-oxobutanoate + NADH + H+ (EC 1.1.1.103)
No genes
L-threonine→acetaldehyde + glycine (EC 4.1.2.48; 4.1.2.5)
mRNA_1891 (10259)
mRNA_1904 (10272)
mRNA_7814 (16182)
mRNA_854 (9222)
Threonine-phosphate decarboxylase:
L-threonine 3-O-phosphate + H+→(R)-1-amino-2-propanol O-2-phosphate + CO2 (EC 4.1.1.81)
No genes
Acetaldehyde dehydrogenase (acetylating):
acetaldehyde + coenzyme A + NAD+→acetyl-CoA + NADH + H+ (EC 1.2.1.10)
No genes
Glycine C-acetyltransferase (in reverse):
L-2-amino-3-oxobutanoate + coenzyme A→glycine + acetyl-CoA (EC 2.3.1.29)
No genes
1-aminocyclopropane-1-carboxylate deaminase:
(2Z)-2-aminobut-2-enoate→2-iminobutanoate (spontaneous) (EC 3.5.99.7; 4.3.1.19; 4.4.1.1; 4.4.1.11; 4.4.1.2)
mRNA_3541 (11909)
mRNA_4566 (12934)
mRNA_1131 (9499)
L-threonine 3-dehydrogenase:
L-2-amino-3-oxobutanoate + H+→aminoacetone + CO2 (spontaneous) (EC 1.1.1.103; 1.1.1.381)
No genes
Primary-amine oxidase:
aminoacetone + dioxygen + H2O→methylglyoxal + ammonium + hydrogen peroxide (EC 1.4.3.21)
mRNA_1940 (10308)
mRNA_5591 (13959)
2-iminobutanoate + H+ + H2O→2-oxobutanoate + ammonium (spontaneous) (EC 3.5.99.10; 3.5.99.7; 4.3.1.19; 4.4.1.1; 4.4.1.11; 4.4.1.2)
mRNA_3541 (11909)
mRNA_4566 (12934)
mRNA_1131 (9499)
mRNA_1489 (9857)
Acetolactate synthase:
2-oxobutanoate + H+ + pyruvate→(S)-2-aceto-2-hydroxybutanoate + CO2 (EC 2.2.1.6)
mRNA_7317 (15685)
mRNA_1432 (9800)
2-oxobutanoate + coenzyme A→propanoyl-CoA + formate
No genes
Ketol-acid reductoisomerase (in reverse):
(S)-2-aceto-2-hydroxybutanoate + NADPH + H+→(R)-2,3-dihydroxy-3-methylpentanoate + NADP+ (EC 1.1.1.86)
mRNA_808 (9176)
mRNA_809 (9177)
mRNA_810 (9178)
propanoyl-CoA + phosphate→propanoyl phosphate + coenzyme A (EC 2.3.1.222)
No genes
Dihydroxy-acid dehydratase:
(R)-2,3-dihydroxy-3-methylpentanoate→(3S)-3-methyl-2-oxopentanoate + H2O (EC 4.2.1.9)
mRNA_6258 (14626)
mRNA_1321 (9689)
Acetate kinase (in reverse):
propanoyl phosphate + ADP→propanoate + ATP (EC 2.7.2.1; 2.7.2.14; 2.7.2.15; 2.7.2.7)
mRNA_5015 (13383)
Branched-chain-amino-acid transaminase (in reverse):
(3S)-3-methyl-2-oxopentanoate + L-glutamate→L-isoleucine + 2-oxoglutarate (EC 2.6.1.42)
mRNA_5646 (14014)
mRNA_6242 (14610)
mRNA_6485 (14853)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information